GHK-Cu: A Peptide with Broad Research Potential

What Is GHK-Cu?

GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper peptide complex first identified in human plasma in the 1970s. Formed when the tripeptide GHK binds to a copper ion (Cu²⁺), it has since been studied extensively across tissue repair, dermatology, and regenerative medicine research. Its biological activity appears to be driven by both copper delivery and broad modulation of gene expression.

Biological Role & Mechanisms

GHK-Cu is understood to operate through two primary mechanisms. First, as a copper transport peptide, it facilitates the safe delivery and bioavailability of copper — an essential cofactor for enzymes involved in collagen crosslinking, angiogenesis, and antioxidant defense. Second, research has demonstrated that GHK-Cu can upregulate or downregulate hundreds of human genes related to tissue remodeling, inflammatory response, and cellular growth — suggesting its actions extend well beyond simple copper delivery.

Current Areas of Research

• Skin & cosmetic science — Studied for its role in stimulating collagen, elastin, and glycosaminoglycan synthesis; investigated in wound-healing and skin firmness models
• Anti-inflammatory research — Evidence suggests GHK-Cu may reduce pro-inflammatory cytokines while promoting anti-inflammatory signaling pathways
• Hair follicle biology — Studies have explored possible roles in stimulating follicle growth and increasing follicle size in model systems
• Tissue repair & regeneration — Preclinical data point toward accelerated wound closure, reduced scar formation, and support for nerve outgrowth
• Epigenetic gene regulation — Investigated for modulation of nuclear factor pathways linked to cell survival and extracellular matrix repair

Research Compound Specifications

Parameter	Specification
Full Name	Glycyl-L-histidyl-L-lysine copper (II)
CAS Number	89030-95-5
Molecular Weight	340.38 g/mol (free peptide)
Form	Lyophilized powder
Purity	≥98% (HPLC verified)
Storage	−20°C, protect from light and moisture
Application	Research use only — not for human or veterinary use

GHK-Cu is supplied strictly as a research compound for laboratory and scientific investigation only. Not approved for human consumption, cosmetic use, clinical application, or diagnostic purposes. All experimentation should be conducted by qualified professionals in appropriate research settings.